An Indian-origin boy Krtin Nithiyanandam, has claimed that, he found the treatment for the most deadly form of breast cancer which is unresponsive to drugs.
The 16-year-old boy hopes he has found a way to turn so-called triple negative breast cancer into a kind which responds to drugs. The teenager was moved to the United Kingdom from India with his parents,
Many breast cancers are driven by oestrogen, progesterone or growth chemicals, so drugs that can block those fuels, like tamoxifen, make effective treatments. Although, triple negative breast cancer does not have receptors and it can only be treated with a combination of surgery, radiation and chemotherapy which lowers the chance of survival.
The Times of India reported, Krtin said that, "I've been basically trying to work out a way to change difficult-to-treat cancers into something that responds well to treatment. Most cancers have receptors on their surface which bind to drugs like Tamoxifen but triple negative don't have receptors so the drugs don't work."
"The prognosis for women with undifferentiated cancer isn't very good so the goal is to turn the cancer back to a state where it can be treated. The ID4 protein actually stops undifferentiated stem cell cancers from differentiating so you have to block ID4 to allow the cancer to differentiate," he said.
"I have found a way to silence the genes that produce ID4 which turns cancer back into a less dangerous state," Krtin said.
He has also developed that upping the activity of a tumour-suppressor gene called PTEN allows chemotherapy to work more effectively, so the dual treatment could prove far more effective than traditional drugs.
He was shortlisted for his therapy idea in the final of the UK-based young scientists programme 'The Big Bang Fair'.